Research Facilities

MBTG trainees have access to many state-of-the-art research instrumentation facilities at UCSD for their research. The MBTG trainees have the privilege of being trained to operate the instruments and analyze their data. Often, data analysis software will be provided to the trainees free of charge. Trainees should contact the faculty member in charge of the instrumentation they want to learn how to use to obtain the necessary training.

Biophysics Instrumentation

Location: Instruments are located in individual faculty's labs

An Aviv CD spectrometer is located in the Tezcan lab in Urey Hall, and a Microcal VP isothermal titration calorimeter is available in the Komives lab in NSB. The use of the instruments is limited to trained users. Each of these instruments has a faculty member in charge. If you would like to become a user, you should first contact Professor Komives, who will arrange for training. Once the faculty in charge of the instrument has approved, you can have access to the instrument.

Biomolecular and Proteomics Mass Spectrometry Facility

Location: Natural Sciences Building (NSB), Room 4309

The Biomolecular Mass Spectrometry Facility houses instrumentation that has mainly been obtained through NIH Shared Instrumentation Grants. Some instruments have also been obtained specifically for research related to the SUPERFUND Basic Research Program. The instruments are primarily for analysis of proteins and peptides with a primary focus on protein identification and characterization of complex mixtures of proteins (proteomics).

Molecular Mass Spectrometry Facility

Location: Urey Hall, Rooms 2237-2265

The MMSF houses a Thermo LCQdeca-MS, a Thermo LCQdeca XPplus MS, a Micromass Quattro Ultima Triple Quadrupole MS, an Agilent 6230 Accurate-Mass TOFMS, a Thermo Traceplus GC-MS, a Thermo MAT900XL high resolution MS, and a Bruker Biflex IV MALDI-TOFMS.

NMR Facilities

Location: Pacific Hall & Natural Sciences Building (NSB)

The NMR Facilities' focus is to provide UCSD researchers and external users with access to NMR services and state of the art NMR equipment. The facility is subdivided into two centers: the Chemistry NMR facility, located in Pacific Hall, and the Biomolecular NMR facility, located in the basement of the Natural Science Building. 

Keck Laboratory for Integrated Biology II

Location: Urey Hall

W. M. Keck Laboratory for Integrated Biology II, a San Diego Supercomputer Center satellite, is a state of the art computational facility established to foster interdisciplinary collaborative research in biological, chemical and physical sciences. Linked with high-bandwidth connections to the other Keck site located at the School of Medicine and to SDSC these facilities form a tightly coupled set of resources to support analysis of molecular and cellular structure and function.

Cryo-Electron Microscopy Facility

Location: Bonner Hall 1501

Cryo-Electron Microscopy Facility. Macromolecular, cryo-electron microscopy and three-dimensional (3D), image-reconstruction techniques are used in our research to visualize viruses and to determine how they interact with their hosts, replicate and mature. Recent technological advances have led to an explosive growth in this field and have allowed researchers to observe molecules and molecular interactions at sub-nanometer resolutions. Microscopists are now more routinely able to trace protein chains, visualize protein-nucleic acid interactions, and to study how lipids play a major role in some enveloped viruses.

Molecular X-Ray Facility

Location: Urey Hall

The Molecular X-Ray Facility is equipped with four state-of-the-art Bruker Single-Crystal Diffractometers with CCD detectors and low-temperature cryostats as well as a state-of-the-art Bruker Powder Diffractometer. Also, a library of graphical routines is available for all forms of data presentation. We can prepare and customize graphics for individual needs.

San Diego Center for Systems Biology

Location: SDSC

The San Diego Center for Systems Biology combines top down and bottom up systems biology approaches to understand the functioning of the regulatory networks that control cellular responses to stress agents such as DNA and metabolic damaging agents, and pathogens. Cellular stress responses are tailored to limit the damage and initiate repair, but when misregulated, they can cause pathology, including chronic inflammatory disease and cancer. Network-emergent properties such as dose response and dynamic control, and systems robustness, are major determinants of an appropriate and healthy cellular stress response.